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在职教师

吕世贤

特聘研究员

邮箱:lvshixian@pku.edu.cn


教育经历:

2010.9-2016.1,博士, 高分子化学与物理国家重点实验室,中国科学院大学, 长春应用化学研究所(CIAC)

2006.9-2010.7,理学学士, 南京大学化学系


工作经历:

2021.9-至今,北京大学,材料科学与工程学院,特聘研究员

2018.9-2021.7,Postdoctoral Fellow,Bioengineering,华盛顿大学

2017.2-2018.9,Postdoctoral Fellow,Materials Science and Engineering,伊利诺伊大学厄巴纳-香槟分校

2016.2-2017.2,Postdoctoral Fellow,The Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University(China)


研究兴趣:

主要研究和关注的方向为生物医用材料、新型高分子、多肽固相合成技术与应用、肿瘤免疫治疗等。


研究成果:

获国家自然科学基金,青年科学基金。已发表SCI论文40余篇(Chemical Society Reviews, Journal of the American Chemical Society,Nano Letters,Small, Biomaterials,Journal of Controlled Release,Nano Research,Nanoscale等 ),其中第一作者发表IF>10的文章5篇。论文被引2000次,H因子22。2篇论文为本领域高被引文章。申请或授权中国专利多篇。


发表论文:

1.Shixian Lv,Meilyn Sylvestre, Alexander N Prossnitz, Lucy F Yang, Suzie H Pun, Design of Polymeric Carriers for Intracellular Peptide Delivery in Oncology Applications,Chemical Reviews,2021, 121(18): 11653-11698.

2.Shixian Lv, Meilyn Sylvestre, Kefan, Song, Suzie H. Pun, Development of D-melittin polymeric nanoparticles for anti-cancer treatment,Biomaterials,2021.

3.Meilyn Sylvestre,Shixian Lv (co-first authors), Lucy F Yang, Nicholas Luera, David J Peeler, Bing-Mae Chen, Steve R Roffler, Suzie H Pun, Replacement of L-amino acid peptides with D-amino acid peptides mitigates antiPEG antibody generation against polymer-peptide conjugates in mice,Journal of Controlled Release, 2021, 331: 142-153.

4.Shixian Lv,Hojun Kim, Lin Feng, Ziyuan Song, Yingfeng Yang, Ryan Baumgartner, Kuan-Ying Tseng, Shen J Dillon, Cecilia Leal, Lichen Yin, Jianjun Cheng, Unimolecular Polypeptide Micelles via Ultra-fast Polymerization of N-Carboxyanhydrides,Journal of the American Chemical Society,2020, 142, 19, 8570–8574.

5. Yuchen Wu,Shixian Lv (co-first authors),Yongjuan Li, Hua He, Yong Ji, Mingfeng Zheng, Yong Liu, Lichen Yin, Co-delivery of dual chemo-drugs with precisely controlled, high drug loading polymeric micelles for synergistic anti-cancer therapy,Biomaterials Science,2020.

6. Yongjuan Li,Shixian Lv (co-first authors), Ziyuan Song, Juanjuan Dang, Xudong Li, Hua He, Xin Xu, Zhuchao Zhou, Lichen Yin. Photodynamic therapy-mediated remote control of chemotherapy toward synergistic anticancer treatment,Nanoscale, 2018, 10(30): 14554-14562.

7.Shixian Lv, Yuchen Wu, Kaimin Cai, Hua He, Yongjuan Li, Min Lan, Xuesi Chen, Jianjun Cheng, Lichen Yin, High drug loading and sub-quantitative loading efficiency of polymeric micelles driven by donor–receptor coordination interactions,Journal of the American Chemical Society,2018140(4), 1235-1238. (highly cited papers)

8.Shixian Lv, Zhaohui Tang, Wantong Song, Dawei Zhang, Mingqiang Li, Huaiyu Liu, Jianjun Cheng, Wu Zhong, Xuesi Chen, Inhibiting Solid Tumor Growth In Vivo by Non‐Tumor‐Penetrating Nanomedicine,Small, 2017, 13(12).

9.Shixian Lv, Yuchen Wu(co-first authors), Jingqi Dang, Zhaohui Tang, Ziyuan Song, Sheng Ma, Xiao Wang, Xuesi Chen, Jianjun Cheng, Lichen Yin, Investigation on the controlled synthesis and post-modification of poly-[(N-2-hydroxyethyl)-aspartamide]-based polymers,Polymer Chemistry, 2017, 8(12): 1872-1877.

10. Qian Li,Shixian Lv (co-first authors), Zhaohui Tang, Muhua Liu, Dawei Zhang, Yan Yang, Xuesi Chen, A co-delivery system based on paclitaxel grafted mPEG-b-PLG loaded with doxorubicin: preparation, in vitro and in vivo evaluation,International Journal of Pharmaceutics, 2014, 471(1-20):412-420.